Anemia aplastik merupakan bentuk anemia yang merupakan sindrom dari kegagalan sumsum tulang, ditandai oleh pansitopenia pada darah tepi dan hipoplasia sumsum tulang.
The incidence rate of aplastic anemia in Asia is 2โ3 times higher than it is in the West; the incidence in the United States is 300โ900 cases per year.
Aplastic anemia is a disease in which the body fails to produce blood cells in sufficient numbers. Blood cells are produced in the bone marrow by stem cells that reside there. Aplastic anemia causes a deficiency of all blood cell types: red blood cells, white blood cells, and platelets.
Anemia aplastik adalah suatu kondisi yang terjadi ketika tubuh berhenti memproduksi cukup sel darah baru. Kondisi ini membuat tubuh lelah dan lebih rentan terhadap infeksi dan pendarahan yang tidak terkontrol. Anemia aplastik adalah kondisi langka dan serius, dapat berkembang pada usia berapa pun.
Anemia aplastik merupakan anemia akibat penurunan tingkat sel darah merah yang disebabkan oleh ketidakmampuan sel induk dalam sumsum tulang untuk memproduksi sel-sel baru. Berbeda seperti anemia pada umumnya, pada anemia aplastik ini tidak hanya sel darah merah yang berhenti produksinya, akan tetapi juga sel darah putih dan trombosit .
What it is. Despite its name, aplastic anemia, or bone marrow failure, is more than anemia. Aplastic anemia is a rare but serious blood condition that occurs when your bone marrow cannot make enough new blood cells for your body to work normally. It can develop quickly or slowly, and it can be mild or serious.
Fanconi anemia is the most common hereditary cause. It presents in the late first decade with pancytopenia, organ hypoplasia, and bone defects including abnormal radii, absent thumbs, and short stature. Seronegative hepatitis is responsible for 5% to 10% of total cases. Telomerase defects are found in 5% to 10% of adult-onset aplastic anemia.
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