The very large difference between unadjusted and adjusted results is due to much higher risk for patients with renal disease and the much bromhexine prevalence of renal disease in the bromhexine group.
Bromhexine is a mucolytic drug used in the treatment of respiratory disorders associated with viscid or excessive mucus. It was originally derived as an extract derivative called vasicinone from the Indian plant, Adhatoda vasica. It was patented in 1961 and came into medical use in 1966.
Bromhexine is known to cross the blood-brain barrier; small concentrations may cross the placenta. The average volume of distribution of bromhexine was 1209 ± 206 L (19 L/kg). Lung tissue concentrations of bromhexine two hours after a dose were 1.5 to 3.2 times higher in bronchial tissues than plasma concentrations.
This open-label randomized controlled pilot study aimed to test the study feasibility of bromhexine hydrochloride (BRH) tablets for the treatment of mild or moderate coronavirus disease 2019 (COVID-19) and to explore its clinical efficacy and safety. Patients with mild or moderate COVID-19 were rand …
Description: Bromhexine is a mucolytic agent that acts on the mucus gland in the respiratory tract to change the structure of bronchial secretion.It enhances the transport of mucus by reducing its viscosity and increases cilia activity resulting in enhanced mucociliary clearance.
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